MMP3 Is a Non-invasive Biomarker of Rejection in Skin-Bearing Vascularized Composite Allotransplantation: A Multicenter Validation Study
Identifieur interne : 000046 ( France/Analysis ); précédent : 000045; suivant : 000047MMP3 Is a Non-invasive Biomarker of Rejection in Skin-Bearing Vascularized Composite Allotransplantation: A Multicenter Validation Study
Auteurs : Branislav Kollar [États-Unis] ; Audrey Uffing [États-Unis] ; Thiago J. Borges [États-Unis] ; Andrey V. Shubin [États-Unis] ; Bruno T. Aoyama [États-Unis] ; Céline Dagot [France] ; Valentin Haug [États-Unis, Allemagne] ; Martin Kauke [États-Unis] ; Ali-Farid Safi [États-Unis] ; Simon G. Talbot [États-Unis] ; Emmanuel Morelon [France] ; Stéphanie Dakpe [France] ; Bohdan Pomahac [États-Unis] ; Leonardo V. Riella [États-Unis]Source :
- Frontiers in Immunology [ 1664-3224 ] ; 2019.
Abstract
Url:
DOI: 10.3389/fimmu.2019.02771
PubMed: 31849957
PubMed Central: 6897344
Affiliations:
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PMC:6897344Le document en format XML
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Borges</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Renal Division, Schuster Transplantation Research Center, Brigham and Women's Hospital and Harvard Medical School</institution>,<addr-line>Boston, MA</addr-line>,<country>United States</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shubin, Andrey V" sort="Shubin, Andrey V" uniqKey="Shubin A" first="Andrey V." last="Shubin">Andrey V. Shubin</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Molecular and Cellular Biology, Harvard University</institution>,<addr-line>Cambridge, MA</addr-line>,<country>United States</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Aoyama, Bruno T" sort="Aoyama, Bruno T" uniqKey="Aoyama B" first="Bruno T." last="Aoyama">Bruno T. Aoyama</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Renal Division, Schuster Transplantation Research Center, Brigham and Women's Hospital and Harvard Medical School</institution>,<addr-line>Boston, MA</addr-line>,<country>United States</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dagot, Celine" sort="Dagot, Celine" uniqKey="Dagot C" first="Céline" last="Dagot">Céline Dagot</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Transplantation, Nephrology and Clinical Immunology, Edouard Herriot Hospital, Hospices Civils de Lyon</institution>,<addr-line>Lyon</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Haug, Valentin" sort="Haug, Valentin" uniqKey="Haug V" first="Valentin" last="Haug">Valentin Haug</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Division of Plastic Surgery, Department of Surgery, Brigham and Women's Hospital and Harvard Medical School</institution>,<addr-line>Boston, MA</addr-line>,<country>United States</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Department of Hand, Plastic and Reconstructive Surgery, Burn Trauma Center, BG Trauma Center Ludwigshafen, University of Heidelberg</institution>,<addr-line>Ludwigshafen</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kauke, Martin" sort="Kauke, Martin" uniqKey="Kauke M" first="Martin" last="Kauke">Martin Kauke</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Division of Plastic Surgery, Department of Surgery, Brigham and Women's Hospital and Harvard Medical School</institution>,<addr-line>Boston, MA</addr-line>,<country>United States</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Safi, Ali Farid" sort="Safi, Ali Farid" uniqKey="Safi A" first="Ali-Farid" last="Safi">Ali-Farid Safi</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Division of Plastic Surgery, Department of Surgery, Brigham and Women's Hospital and Harvard Medical School</institution>,<addr-line>Boston, MA</addr-line>,<country>United States</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Talbot, Simon G" sort="Talbot, Simon G" uniqKey="Talbot S" first="Simon G." last="Talbot">Simon G. Talbot</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Division of Plastic Surgery, Department of Surgery, Brigham and Women's Hospital and Harvard Medical School</institution>,<addr-line>Boston, MA</addr-line>,<country>United States</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Morelon, Emmanuel" sort="Morelon, Emmanuel" uniqKey="Morelon E" first="Emmanuel" last="Morelon">Emmanuel Morelon</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Transplantation, Nephrology and Clinical Immunology, Edouard Herriot Hospital, Hospices Civils de Lyon</institution>,<addr-line>Lyon</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dakpe, Stephanie" sort="Dakpe, Stephanie" uniqKey="Dakpe S" first="Stéphanie" last="Dakpe">Stéphanie Dakpe</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Department of Maxillo-Facial Surgery, Amiens University Hospital</institution>,<addr-line>Amiens</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pomahac, Bohdan" sort="Pomahac, Bohdan" uniqKey="Pomahac B" first="Bohdan" last="Pomahac">Bohdan Pomahac</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Division of Plastic Surgery, Department of Surgery, Brigham and Women's Hospital and Harvard Medical School</institution>,<addr-line>Boston, MA</addr-line>,<country>United States</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Riella, Leonardo V" sort="Riella, Leonardo V" uniqKey="Riella L" first="Leonardo V." last="Riella">Leonardo V. Riella</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Renal Division, Schuster Transplantation Research Center, Brigham and Women's Hospital and Harvard Medical School</institution>,<addr-line>Boston, MA</addr-line>,<country>United States</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Immunology</title><idno type="eISSN">1664-3224</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Background:</bold> There is unmet need for non-invasive immunomonitoring to improve diagnosis and treatment of acute rejection in vascularized composite allotransplantation (VCA). Circulating matrix metalloproteinase 3 (MMP3) was described as a candidate non-invasive biomarker to predict treatment response to acute rejection in clinical VCA. However, larger validation studies are yet to be reported to allow for more definitive conclusions.</p><p><bold>Methods:</bold> We retrospectively measured MMP3 levels using ELISA in a total of 140 longitudinal serum samples from six internal and three external face transplant recipients, as well as three internal and seven external upper extremity transplant recipients. The control groups comprised serum samples from 36 kidney transplant recipients, 14 healthy controls, and 38 patients with autoimmune skin disease. A linear mixed model was used to study the effect of rejection state (pre-transplant, no-rejection, non-severe rejection (NSR), and severe rejection) on MMP3 levels.</p><p><bold>Results:</bold> In VCA, MMP3 levels increased significantly (<italic>p</italic> < 0.001) between pre- and post-transplant no-rejection states. A further increase occurred during severe rejection (<italic>p</italic> < 0.001), while there was no difference in MMP3 levels between non-severe and no-rejection episodes. A threshold of 5-fold increase from pre-transplant levels could discriminate severe from NSR with 76% sensitivity and 81% specificity (AUC = 0.79, 95% CI = 0.65–0.92, <italic>p</italic> < 0.001). In kidney transplantation, the MMP3 levels were significantly (<italic>p</italic> < 0.001) elevated during antibody-mediated rejection but not during T-cell mediated rejection (TCMR) (<italic>p</italic> = 0.547). MMP3 levels in healthy controls and autoimmune skin disease patients were comparable with either pre-transplant or no-rejection/NSR episodes of VCA patients.</p><p><bold>Conclusion:</bold> The results of this study suggest that serum MMP3 protein is a promising marker for stratifying patients according to severity of rejection, complementary to biopsy findings.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Tasigiorgos, S" uniqKey="Tasigiorgos S">S Tasigiorgos</name></author><author><name sortKey="Kollar, B" uniqKey="Kollar B">B Kollar</name></author><author><name sortKey="Turk, M" uniqKey="Turk M">M Turk</name></author><author><name sortKey="Perry, B" uniqKey="Perry B">B Perry</name></author><author><name sortKey="Alhefzi, M" uniqKey="Alhefzi M">M Alhefzi</name></author><author><name sortKey="Kiwanuka, H" uniqKey="Kiwanuka H">H Kiwanuka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kollar, 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uniqKey="Kantar R">RS Kantar</name></author><author><name sortKey="Diaz Siso, Jr" uniqKey="Diaz Siso J">JR Diaz-Siso</name></author><author><name sortKey="Gelb, Be" uniqKey="Gelb B">BE Gelb</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garcia, Tp" uniqKey="Garcia T">TP Garcia</name></author><author><name sortKey="Marder, K" uniqKey="Marder K">K Marder</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>France</li><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Kollar, Branislav" sort="Kollar, Branislav" uniqKey="Kollar B" first="Branislav" last="Kollar">Branislav Kollar</name></noRegion><name sortKey="Aoyama, Bruno T" sort="Aoyama, Bruno T" uniqKey="Aoyama B" first="Bruno T." last="Aoyama">Bruno T. Aoyama</name><name sortKey="Borges, Thiago J" sort="Borges, Thiago J" uniqKey="Borges T" first="Thiago J." last="Borges">Thiago J. Borges</name><name sortKey="Haug, Valentin" sort="Haug, Valentin" uniqKey="Haug V" first="Valentin" last="Haug">Valentin Haug</name><name sortKey="Kauke, Martin" sort="Kauke, Martin" uniqKey="Kauke M" first="Martin" last="Kauke">Martin Kauke</name><name sortKey="Pomahac, Bohdan" sort="Pomahac, Bohdan" uniqKey="Pomahac B" first="Bohdan" last="Pomahac">Bohdan Pomahac</name><name sortKey="Riella, Leonardo V" sort="Riella, Leonardo V" uniqKey="Riella L" first="Leonardo V." last="Riella">Leonardo V. Riella</name><name sortKey="Safi, Ali Farid" sort="Safi, Ali Farid" uniqKey="Safi A" first="Ali-Farid" last="Safi">Ali-Farid Safi</name><name sortKey="Shubin, Andrey V" sort="Shubin, Andrey V" uniqKey="Shubin A" first="Andrey V." last="Shubin">Andrey V. Shubin</name><name sortKey="Talbot, Simon G" sort="Talbot, Simon G" uniqKey="Talbot S" first="Simon G." last="Talbot">Simon G. Talbot</name><name sortKey="Uffing, Audrey" sort="Uffing, Audrey" uniqKey="Uffing A" first="Audrey" last="Uffing">Audrey Uffing</name></country><country name="France"><noRegion><name sortKey="Dagot, Celine" sort="Dagot, Celine" uniqKey="Dagot C" first="Céline" last="Dagot">Céline Dagot</name></noRegion><name sortKey="Dakpe, Stephanie" sort="Dakpe, Stephanie" uniqKey="Dakpe S" first="Stéphanie" last="Dakpe">Stéphanie Dakpe</name><name sortKey="Morelon, Emmanuel" sort="Morelon, Emmanuel" uniqKey="Morelon E" first="Emmanuel" last="Morelon">Emmanuel Morelon</name></country><country name="Allemagne"><noRegion><name sortKey="Haug, Valentin" sort="Haug, Valentin" uniqKey="Haug V" first="Valentin" last="Haug">Valentin Haug</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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